Peter Attia· MD
adiponectin is an adipocine secreted by fat that has an inverse relationship to insulin resistance so you know basically people who are insulin resistant of lower levels and people who are you know more insulin sensitive and adiponectin itself appears to have some direct effect on HDL metabolism in the right direction we could talk about it possibly by tweaking the liver and ways that then the liver affects HDL so where I'm really going with this although I have to say the data still are not completely solid is that another way that insulin resistance is impacting on HDL is through a dipinectin secretion affecting HDL metabolism in a way that's completely different than the triglyceride hypothesis that I just put forth