Atherosclerosis progression involves changes that occur long before significant luminal narrowing is present.

“the real way to think about this is to and I think Ron and I talked about this at length in the podcast is to look at a pathology textbook when you look at the autopsies you'll get a sense of what's going on long before you have luminal narrowing which may or may not accompany a problem you have a very clear documented path of what this disease does”