Humans could efficiently clear APOB at a much greater rate to achieve an APOB concentration of approximately 20 mg/dL instead of 100 mg/dL, which would prevent atherosclerosis.

“it's really not that we don't need APO B it's that we could be clearing it at a much greater and more efficient rate than we are and we could more mimic primates and other men animals and walk around with an apob concentration of call it 20 milligrams per deciliter instead of 100 milligrams per deciliter a five-fold difference which is about that's the difference between getting atherosclerosis In Our Lifetime and never getting atherosclerosis in our lifetime”