Apolipoprotein B (ApoB) is a structural protein that tags atherogenic lipoproteins like LDL, VLDL, IDL, and Lipoprotein(a).

“that kind of runs through it as a structural protein called an apob I know you guys are familiar with it because we've talked about it a lot but an April B kind of is what tags the low density lipoprotein and vldl ideal and lipoprotein little a the more atherogenic uh uh lipoproteins as you know the the B structures they have this B structure on it”

“he talked about hey Apel be 100 Apel be 48th Apel be is a giant structural non-transferable”

“April B never does for a bunch of reasons it provides the structural integrity to that particle throughout to the existent but April B turns out to be the ligand for receptors that internalize those particles when you your body don't need them anymore”

“APO b as your listeners know APO B stays with that particle throughout its lifetime so it gets made by the intestines b48 or the liver is B100 it stays with that particle there's one molecule of this huge APO B protein and that it basically then ultimately gets taken up mostly by the liver after its time in the blood”

“so scientifically we have to zero in on what regulates clearance of these particles and the simplest thing is to say well the only way these APLE B particles get cleared is our liver produces something called an LDL receptor which migrates to the surface of the liver cell that interacts with the blood flow the plasma and these LDL receptors are Engineers to recognize any apob B peptide that floats by it so if an LDL particle containing apob floats by an LDL receptor it will get grabbed and then it gets internalized into the ldo receptor and it gets catabolized and then the liver can take whatever cholesterol triglycerides fatty acids blah blah blah is in that molecule and use it for other purposes or somehow get rid of it in the bilary system if the liver doesn't need it”