Small, dense LDL particles lodging in the arterial wall, combined with LPS signaling, can initiate foam cell formation and atherosclerosis.

“what happens is that small antel LDL particle lodges itself in your arterial wall and because the LPS is a signal for the immune system hey bacterial invader here the first line of defense is macrofasages it's a type of immune cell that come and engulf bacteria they eat bacteria up so that it doesn't kill you well they come thinking it's bacteria but really it's a small dense LDL particle lodged in your artery you got this macroof phase it tries to eat it only it can't because it's stuck to an LDL particle and so now you have the beginnings of what's called a foam cell it's like a macrofase there and it's you know making cytoines and stuff and now bringing more and so you have the the start of atheroscerosis all coming from gut permeability all coming from LPS leaking out into circulation”