Lactate accumulation leading to muscle acidosis is observed in the acidic microenvironment of cancer.

“when you have a lot of when you don't have the right mct1 and mitochondrial function uh this lactate is going to increase and accumulate right and it's not lactate per se but the hydrogen ions Associated to lactate elicit an um um acidosis of the micro environment of the muscle which is something that we know and we have learned also from cancer the famous cancer micro environment which is very acidic and that's going interfere with different functions in the muscle with both the um the um the the contractive force and the velocity of the muscle fibers”