Peter Attia· MD
PCSK9 inhibition might also increase Lp(a) catabolism
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
PCSK9 inhibition might also increase Lp(a) catabolism
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we know that LP little a is cleared by different receptors so it's primary receptor is probably lrp - but it's also probably cleared somewhat by VLDL receptors and even something called SRB one
we're still not entirely sure of how the catabolism of lpa occurs we we've it's probably by well most of it is by the liver there's a little bit by the a little bit of catabolism by the kidney as well