Peter Attia· MD
if you inherited two copies of APO E2 that form of apoe is defective in binding to the LDL receptor and the other receptors that mediate uptake of Remnant lipoproteins both chylomicron remnants and bldl Remnants
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
if you inherited two copies of APO E2 that form of apoe is defective in binding to the LDL receptor and the other receptors that mediate uptake of Remnant lipoproteins both chylomicron remnants and bldl Remnants
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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therefore if you homozygous for apoe2 you're at risk for so-called again the terminology is bad type 3 hyperlipidemia which is basically a Remnant clearance disorder these individuals can't clear their remnants appropriately they get high triglycerides and cholesterol they also are at increased risk of atherosclerto cardiovascular disease