The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
it's for that reason that I really prefer looking at the LP little a particle number which even though it's reported in an animal per liter to my knowledge is not actually measured via NMR the way LDL P and HDL P pioneered by lipo science it's a different assay but nevertheless it is counting the a PO little A's that are attached to little a PO B's and so you're getting a number of those
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when a patient shows up and their LP little a mass is really really low like less than 5 milligrams per deciliter the likelihood that their LP little a particle number is very high is really really low
it turns out that the guy that's got more particles is at higher risk
i also just as i've sort of iterated about other lipoproteins i think when we're talking about lp little a in the year 2020 we are talking about all right let's what's its mass what's its lp little a particle number but i also think we have to be smarter on understanding the quality or other attributes of this lp little a particle
if you have an lpa measured in milligrams per deciliter and it puts you in a high risk range so let's say you're you're it it gives you an lpa level of above 50 then the chances of the lpa assay that's that will give you a result in nanomoles per liter it will also give you a high a high level
we think that the milligram per deciliter mass measurement is probably sufficient
and uh there's there's more and more labs that are that are doing this and this is clearly the the way to go we have to move away from measurements in in milligrams per deciliter which is really influenced by the isoform size of lpa and the measurement in nanomolar will actually give you a much better sense of the number of lpa particles in the circulation and that's what we should be uh aiming at
it's the mass of the particles so so it's a much better measurement than lpa cholesterol that you that you just referred to
so what you really want to do is try to find a lab that will give you an an lpa measurement in in nanomoles per liter
and there's more and more labs that are that are doing this and this is clearly the the way to go we have to move away from measurements in in milligrams per deciliter which is really influenced by the uh isoform size of lpa and the measurement in uh nanomolar will actually give you a much better sense of the number of lpa particles in the circulation and that's what we should be uh aiming at