A 1980 clinical paper found a marked difference in apoB between patients with clean coronaries and those with diseased coronaries, suggesting particles may be more important than cholesterol.

“1980 was my first paper uh clinical paper showing with peter quitterrich the late pete quitter rich from hopkins and and we looked at a bunch of patients with coronary angiography and we compared people with clean coronaries like clean to people with diseased coronaries like disease and there was there was a little difference in triglyceride there was a difference in cholesterol but there was a marked difference in apop and and that was the first i think clinically solid observations”