The impact of PUFA and SFA substitution with MUFAs on cardiovascular disease is ambiguous in overnutrition, but MUFAs are likely most important in adequate nutrition.

“if I came away from this with anything it's that I don't know how much any of that stuff matters once you're in energy balance in other words in the context of over nutrition I think it all is bad in the context of adequate nutrition the ambiguity in these data were enormous and you know I was left basically thinking look on the basis of predimed and the Leone heart study in addition to some epidemiology mufas probably the most important fatty acid and therefore let's just call it 50 of your fat intake should probably be mufa”