Peter Attia· MD
what most people don't know I think is that an LDL particle is more likely to come back out when it goes in there than it is to stay in there that's good news HDL particles always come out of there
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
what most people don't know I think is that an LDL particle is more likely to come back out when it goes in there than it is to stay in there that's good news HDL particles always come out of there
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the number of vldls that get into the artery wall are infinitesimal the number of kylos that get in are infinitesimal compared to the number of LDL particles so yet are all bad guys they and a vo the L per particle have significantly more cholesterol molecules in it than in LDL but there are just so many more LDLs that collectively the LDLs deliver more cholesterol to that artery water
it's the the number of april-b particles that primarily is what forces it into the artery walls
even though you have way way more LDL particles than you do have VLDL particles because VLDL particles are two or three times bigger than LDL the volume of the spear is the third power of the radius they do carry more cholesterol molecules per particle than an individual LDL particle but of course you have so many more LDL particles and even VLDL or whatever you think of Veolia remnant is most of the cholesterol getting into your artery wall is still LDL delivered but I am not denying that v LDL particles cannot deliver cholesterol and get oxidized when they are into the artery wall they can
not to say a vldl remnant might not be a very injurious apob containing particle it certainly is in some people but if we're looking at the number which is the primary driving force as to how an apob particle enters the artery wall ldl is king and that's why our metrics of april b or ldl particle count are what are at the top of all the guidelines and of course the metric most people use are ldl cholesterol and non-hdl cholesterol