High blood pressure in kidneys is associated with low-grade inflammation driven by T cells and macrophages, which reduces blood flow and impairs salt excretion.

“people with high blood pressure have um inflammation in their kidneys they have low grade inflammation in their kidneys and it's due to a t cells and macrophages and they tend to be in the in the um main part of the kidney where we call the tubules and where the tubules are and uh and around the little blood vessels and we were able to prove that the inflammation was actually maintaining the kidney in a in a state where it could couldn't get rid of salt very well and it did this be by basically creating a reduced blood flow to the kidney”