Paul Saladino· MD
I think there's some compelling data that LDL is beneficial for humans that and that LDL is protective
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
I think there's some compelling data that LDL is beneficial for humans that and that LDL is protective
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yeah and I think you know that that again that's one thing I changed my mind on that I've pretty much pretty strong belief about it and um you know it's kind of like well how much evidence do you need like you know we we still have kind of LDL denialists out there and I think it's one of the I think it's one of the most dangerous things I see actually yeah I mean like you have the mechanism the penetration of the endothelium it's very clear that that happens we have the animal models that show linear dose dependent effects the other mendelian randomization and you have the clinical trials in humans it's and you have the prospective cohort studies and then you have the you have the genetic studies so right you have the pcsk9 over and under expressors
I mean like you have the mechanism the penetration of the endothelium it's very clear that that happens we have the animal models that show linear dose dependent effects