Mendelian randomization studies can be misleading when accounting for intermediate variables like triglycerides and non-HDL cholesterol or apob. — Whalespan
Mendelian randomization studies can be misleading when accounting for intermediate variables like triglycerides and non-HDL cholesterol or apob.
⚠ High risk
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
◐PARTIALLYSUPPORTED
⚠
High-risk intervention — consult a physician before acting.Drug-drug interactions, dose-dependence, and screening contraindications apply.
“but it's like any methodology no method is perfect this one can mislead you to particularly when you've got a sequence of associated variables for example people show using Mr that triglycerides were quote causing or associated with increased risk but when you took into account the non-hdl cholesterol or the apob disappears”