Environmental and lifestyle factors can negatively affect LDL receptor expression, decreasing hepatic clearance of ApoB particles.

“those nuclear transcription factors migrate into the nucleus and the nucleolus of our cells and they bind to specific parts of the DNA until our genes produce this protein produce that protein this enzyme that enzyme this receptor that receptor that can go out and help restore sterile homeostasis to this human body so we could probably every adversarial thing you've been told in your life not to do gain weight don't eat this don't eat that are all affecting these nuclear transcription factors that are going to regulate clearance of these apob particles”