The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
if we look across people with familial hypercholesterolemia in general there is no difference in the incidence of cardio cardiovascular disease given for a given level of LDL and those people it's not clear that that LDL is directly even tied to cardiovascular disease directly in them
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
and there are recent studies that show that they're different monogenetic and polygenetic at likewise levels of LDL have uh uh different outcomes U monogenetic tends to have a worse outcome that one change versus the poly tends to have a higher Association of cardiovascular disease but not as high as monogenetic of of around the same levels
it's interesting I mean obviously suggest some other genetic modifier or something else that protects them