Cells are not deprived of cholesterol when plasma lipid levels are modulated, as they can synthesize cholesterol or obtain it from other sources.

“virtually every cell in your body even if that's your plasma ldl cholesterol has more than enough cholesterol because it can denovo synthesize it or put it in its cell membranes or other organelles that require cholesterol”

“there's no cell that's being deprived of cholesterol in the periphery when you are modulating lipids through lifestyle or drugs”

“the amount of cholesterol within your lipoproteins has no correlation with your cellular cholesterol or even your red blood cell cholesterol so whatever however you're modulating some LDL total cholesterol HDL cholesterol metric that tells you nothing about what might you be doing to the cholesterol content of your cells”

“don't have a panic attack if you're making LDL cholesterol 30 because I can assure you virtually every cell in your body even if that's your plasma LDL cholesterol has more than enough cholesterol because it can de novo synthesize it it can put it in its cell membranes or other organelles that require cholesterol if it's a stereogenic steroidogenic tissue can produce a little more or perhaps delibidate someone so there's no cell that's being deprived of cholesterol in the periphery when you are modulating lipids through lifestyle or drugs”