The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
there's also literature to show that if you if you correct the apob or LDL concentration for the concentration of LDL that is oxidized for something called LP little a then LDL itself fails to be a predictor of cardiovascular disease
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Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
LDL by itself is a piss-poor predictor of cardiovascular disease and we know that oxidized LDL LP little a are much much better metrics
I don't think we should be focusing on LDL I think we should be focusing on LP little a which is a much better risk factor oxidized LDL in the arterial wall
and what we know is that when LDL gets into that vessel wall your cardiovascular risk is elevated if that LDL gets oxidized