The lipid hypothesis, positing that high concentrations of apoB-containing lipoproteins drive atherosclerosis, has roots in 1970s work on the LDL receptor.

“the best way to start in discussing the lipid hypothesis this hypothesis that the higher level of concentration of cholesterol and particularly I would say the modern version being apob containing lipoproteins that this higher concentration drives atherosclerosis really has a lot of its Genesis in the 70s with brown and Goldstein Brown and Goldstein who would then go on to win the Nobel Prize for their work with the LDL receptor uh were looking at seminal patients who had homozygous familial hypercholesterolemia”