Excess saturated fat intake negatively impacts liver nuclear transcription factors that regulate lipid balance, leading to decreased hepatic clearance of apoB particles.

“sure the saturated fat is uh a little easier to explain we have plenty of studies that Show Excess saturated fat uh those genes that are regulating lip or those nuclear transcription factors that are regulating lipid balance in the liver and the liver is the master controller of lipid homeostasis in the body It Works hand inand with the intestine but the liver is sort of the brains of the operation so uh in many many people exposure to saturated fat the nuclear transcription factors realize oh my God the fatty liver”