Peter Attia· MD
The reason is simple: why import what you can make yourself? Although PCSK9i reduce circulating (serum) cholesterol, the brain remains unaffected because it doesn’t rely on serum cholesterol in the first place.
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
The reason is simple: why import what you can make yourself? Although PCSK9i reduce circulating (serum) cholesterol, the brain remains unaffected because it doesn’t rely on serum cholesterol in the first place.
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everything I've talked about cholesterol today that we're measuring in the blood has zero to do with cholesterol in the brain cholesterol lipid ology in the brain is might as well be in another different body it has nothing to do with what's the cholesterol is going on and the rest your body the brain makes every cholesterol molecule it needs
so Evolution I guess figured out a long time ago that the brain needs cholesterol so we're not going to make the brain dependent on cholesterol that's floating around the plasma or what's in your liver or your intestine we're going to let the brain make all the cholesterol it needs so we're going to really drive the enzymes that uh synthesize cholesterol in the brain
there is no cholesterol carrying particle in the plasma be it a vldl an HDL uh or an LDL that crosses the bloodb brain barrier and says okay brain here's your cholesterol for today doesn't happen
Every cholesterol molecule that's in the brain got there by denovo synthesis in the brain not a single molecule of cholesterol was delivered from the periphery meaning that floating around our plasma leaves the plasma and enters the brain
cholesterol synthesis in the brain starts in utero early on Mom Supply in the little fetal brain with a lot of cholesterol but very rapidly second third trimester those brain cells start making their own cholesterol once a child is born there's a lot of cholesterol synthesis going on on by virtually every cell that exists in the brain
the brain is by far the most cholesterol carrying organ in the body the brain actually makes more cholesterol than any other organ per se way more than the liver even
in infancy and childhood and utero alod dendrites asites and neurons are making cholesterol