Free ApoA1 can cross the blood-brain barrier and join ApoE-containing brain lipoproteins.

“if APO A1 can dissociate from an HDL and we do have free HDL in the plasma that's measurable it is small enough that it can cross the bloodb brain barrier and once it joins the bloodb brain barrier what is the small APO A1 looking for an HDL buoyancy particle so it joins with the apoe particles so the brain lipoproteins are all apoe or they're all apoe plus apoa1 and you can have multiple copies of each of those on those particles”

“what is the smallest apil protein the body can make it's actually apil protein A1 which is why an HDL needs four or five of them so if apoa1 can dissociate from an HDL and we do have free HDL in the plasma that's measurable it is small enough that it can cross the bloodb brain barrier and once it joins the bloodb brain barrier what is the small APO A1 looking for an HDL buoyancy particle so it joins with the apoe particles”

“what is the main structural protein in the brain APO e so when an asite makes an lipoprotein it's an APO e containing lipoprotein and by the way they're smaller much smaller than the particles the bra that we find in the periphery if we put them in a cuge they have the density of a high density lipoprotein that W floats around the periphery so they're often called brain hdls”