The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
if APO A1 can dissociate from an HDL and we do have free HDL in the plasma that's measurable it is small enough that it can cross the bloodb brain barrier and once it joins the bloodb brain barrier what is the small APO A1 looking for an HDL buoyancy particle so it joins with the apoe particles so the brain lipoproteins are all apoe or they're all apoe plus apoa1 and you can have multiple copies of each of those on those particles
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the brain also has a lipoprotein delivery system but here's the difference what is the main structural protein in the periphery APO b or APO A1 what is the main structural protein in the brain APO e so when an asy makes an lipoprotein it's an APO e containing lipo protein and by the way they're smaller much smaller than the particles the bra that we find in the periphery if we put them in a cuge they have the density of a high density lipoprotein that would floats around the periphery so they're often called brain hdls but don't confuse brain hdls with peripheral hdls cuz most of the brain hdl's have APO e as their structural protein in the periphery they have a A1
what is the smallest apil protein the body can make it's actually apil protein A1 which is why an HDL needs four or five of them so if apoa1 can dissociate from an HDL and we do have free HDL in the plasma that's measurable it is small enough that it can cross the bloodb brain barrier and once it joins the bloodb brain barrier what is the small APO A1 looking for an HDL buoyancy particle so it joins with the apoe particles
what is the main structural protein in the brain APO e so when an asite makes an lipoprotein it's an APO e containing lipoprotein and by the way they're smaller much smaller than the particles the bra that we find in the periphery if we put them in a cuge they have the density of a high density lipoprotein that W floats around the periphery so they're often called brain hdls