Peter Attia· MD
apoB100 family = VLDL, IDL, LDL, lp(a)
The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
apoB100 family = VLDL, IDL, LDL, lp(a)
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if we're going to talk about the apo b100 family and i'm probably not going to use the term 100 anymore we're talking about very low density lipoproteins intermediate density lipoproteins and low density lipoproteins and of course part of the ldl family is lipoprotein little a if you happen to produce that not everybody does to significant amounts
apob 100 which defines the lineage of lipoproteins that are terms you've probably heard of vldl idl ldl lp little a
broadly speaking these lycoproteins traffic in two types of families a family that is defined by apob which is a lipoprotein that wraps around it or an APA like the protein that wraps around this spherical larger lipoprotein and APO a there's an apoa family there's an APO B fan technically there's two apob families there's an apob 100 and an apob48 I'm going to ignore the APO b48 right now that just exists on chylomicrons and we could do another class on that on another day but for now we're going to focus on apob 100 which defines the lineage of lipoproteins that are terms you've probably heard of vldl IDL LDL LP little a and the APO a lipoproteins Define a totally different class of these called hdls
apob is short for APO lipoprotein b00 which is the structural apoprotein that sits on low density lipoproteins abbreviated ldls I intermediate density lipoproteins abbreviated idls