Two distinct SNPs in the Lp(a) region showed a dose-response effect on Lp(a) levels and a proportional effect on heart disease risk.

“there were i think three studies that were all published in 2009 the first one was the one uh by robert clark from the uk they use the pro-cardis consortium which were if i recall well there were 3000 people with heart disease and 3000 controls and they've identified two snips in the lpa regions that are completely different uh from from one another from one another and they you really saw the the the dose response effect of these snips on lpa levels with a proportional uh effect on the risk of heart disease”