Dysfunctional HDL, even in high levels, may not perform its antioxidant or cholesterol clearance functions effectively.

“there's data that shows people with very high levels of HDL they're actually producing dysfunctional hdls that aren't doing their job to go around as an antioxidant to go after excess cholesterol that was deposited in the periphery that's no longer being utilized and to bring that map to deliver for reprocessing”