Peter Attia· MD
the LDL receptor did everybody so the ligand just forgives them some people listening it's like the key that fits into the lock if their receptor is the lock the ligand is the key
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
the LDL receptor did everybody so the ligand just forgives them some people listening it's like the key that fits into the lock if their receptor is the lock the ligand is the key
Every Sunday: the week’s new conflicts and verdict changes — and nothing else.
Native comments, Twitter mentions, and Reddit threads about this claim — surfaced together so the conversation isn't fragmented across platforms.
Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
Would love a "what would change this verdict" RSS feed. Sign me up if it exists.
And the other thing you mentioned, which I'll come back to, is that the smaller particles, and, in fact, this is an important feature of these smaller particles that I didn't mention earlier, but may actually be one of the more important reasons that they're associated with heart disease risk, is they have less affinity for the LDL receptor. That's been shown by us and by others, that as the particle shrinks to a smaller size, the region of the particle that is recognized by the LDL receptor, which is actually a region of the ApoB protein, that is the receptor recognition site for the whole particle, gets to be obscured, it