Nociceptive pain is caused by tissue nociceptor activation and responds to analgesics like acetaminophen, NSAIDs, COX-2 inhibitors, and opioids.

“Um, one is no susceptive pain. And you'll note that that word no susceptive sounds very similar to noceptors and it's by design. It means that it is pain caused by activation of primary noceptors, whether it be in your skin or soft tissues or viscera. And it tends to have certain qualities. It's very easy to localize. Uh you know exactly where it is. It has a certain intensity. That no susceptive pain tends to be timelmited. Responds well to short-term use of analesic agents. Uh acetaminophen uh NSAIDs, COX 2 inhibitors, uh opioids and it tends to go away.”