Paul Saladino· MD
i tried to make the case for what i'd like to call the lipid profile versus lipoprotein-centric viewpoint
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The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
i tried to make the case for what i'd like to call the lipid profile versus lipoprotein-centric viewpoint
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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lipoprotein it's not a laboratory metric you want to tell me what the LDL cholesterol is the olio particle number is the lipid omix of an LDL is the LDL oxidized are not great we do have asses that will measure that so let's please all you don't identify yourself as an ignoramus and like I've told this to many of the top lipid ologist in a country let you stop telling people what your LDL ask them what is your LDL cholesterol what's your if we don't all talk to talk you're never gonna understand the process
i think we certainly have to know its particle concentration but i like to talk about particle quality so what are the other attributes of any lipoprotein that might contribute to its atherogenicity or in some perhaps not understood make it relatively it's not going to generate atherosclerosis and there certainly have to be things like that going on
where the the it's it's another example an unfortunate sad example they're trying to quiet quantify lipoproteins based just on lipids is not adequate you're not capturing all the information that you should
but I'm talking more and more now when I discuss any type of lipoprotein I don't care which subgroup you want to talk about I think we certainly have to know it's particle concentration but I like to talk about particle quality so what are the other attributes of any lipoprotein that might contribute to its athergenicity or in some perhaps not understood meaning make it relatively it's not going to generate atherosclerosis and there are certainly have to be things like that going on so as we're getting smarter we're looking at other components of the lipoproteins that could be other proteins that are on them that could be their complex lipidome and trying to see aha can that help us discern whether in you a given particle concentration is more worrisome than it is in the next and the next person