ApoB protein synthesis by the liver is under tonic stimulation, suggesting an inefficient process designed for rapid release of VLDL particles.

“The ApoB protein is constantly synthesized by the liver. It's under a tonic stimulation. It's not much regulated, it's just continually being produced and degraded, which seems like a very inefficient process. But one of the thoughts that has intrigued me and others is that the regulation of ApoB and the particles that are formed on ApoB, the VLDL particles, is really to get these particles out in a hurry when they're needed, because VLDL, it's a huge particle relatively speaking to most other biological proteins.”