Larger, buoyant LDL particles are more cardio-protective than small, dense LDL particles because they transport fatty acids and cholesterol to cells.

“we have plenty of evidence that yeah it's no good to have an increased total ldl particle count but if trying not to have too many small ldl particles because the evidence has certainly emerged that particle for particle they're probably more atherogenic than the more buoyant larger ldl particles”

“small, dense = more dangerous... large, buoyant less so.”

“you know the larger buoyant ldl seems to be more cardio protective because it is transporting you know fatty acids and cholesterol and things to cells and um it's the small dense ones that really kind of get stuck in the arteries and start this inflammatory cascade”