Paul Saladino· MD
The original intent of his study was to take lean mass hyperresponders people who are on ketogenic sometimes carnivore sometimes not diets and have very high LDLs like I said the average LDL is over 270 to get an original CT coronary angiogram they may have used clearly specifically I forget. Yeah. and then to do it one year later and to look at plaque progression because I mean maybe I think you could speak to this better than I can but my impression is that most people in the lipid space would say if your LDL is around 300 you should see plaque progression in a year if apo is really driving heart disease independently and so I'll let you talk about it but I think it's an incredible study yeah the patients that come to me oftentimes you know with those types of LDL levels right their doctors have made it sound like they are gonna drop dead tomorrow, right? This go to the hospital now. Yeah. You you gotta do something about this. And here we now have data to show that one year later, like you said, with this exposure to the high LDL levels. And important to point out that in order to get into this study, you had to have been on the diet for at least 3 years before the initial scan. Right? So now for the second scan, you're on at least four years of this diet. you've had this increased LDL for that time. And so you're right, we would expect if LDL was what it's purported to be that we should see significant progression of plaque during this time and they didn't.