A permeable blood-brain barrier may impair glymphatic flow, hindering brain waste clearance.

“the bloodb brain barrier is essential for removing toxic compounds from the brain and um a variety of different processes you know happen to allow this to occur so um for example you you activate the glymphatic system during sleep right and a lot of people are aware of this your brain sort of swells during sleep and the lymphatic system is pushing the cerebral spinal fluid through the brain clearing out debris um amalo plaques you know things like that well that doesn't you need the blood brain barrier to be intact for that to to occur”