Individuals with cognitive decline are poor at clearing amyloid and tend to maintain it in the body.

“So, as you know, it's become clear that you change, your cells change states. You have the metabolic flexibility, you have burning this, burning that for fuel, one of the states you change back and forth between a pro-inflammatory state, essentially an NF-KappaB-mediated state, and on the other hand, an anti-inflammatory, a state that is involved more with SIRT1. These two actually have multiple sites of mutual inhibition. So you're literally flipping back between these different states, and the people who had cognitive decline are poor at getting rid, they're literally keeping this amyloid around.”