APOE4 can accelerate inflammatory responses in the brain following injury, amplifying risk.

“in other settings Apple E4 can you know still increase risk of uh worse cognitive outcomes if you want to put it that way and the setting of traumatic brain injury you know it's like an acute brain injury or a stroke or maybe even more of a chronic type brain injury you know associated with for systemic health or lifestyle Apple E4 seems to you know accelerate um or increase the the sort of inflammatory responses into the brain to those kinds of insults and that's maybe why it can sort of amplify um the the risk in the sort of the modern environment which seems to not be particularly good uh for the brain in general”