Genetic forms of small vessel disease, such as CADASIL and CARASIL, involve pericytes and vascular smooth muscle cells, leading to early onset white matter disease and rapid cognitive decline.

“in terms of small vessel disease there is two diseases that are quite known now and quite studied uh one is called cadazio the other one is called called Carousel and interestingly these two diseases involve parasites and Vascular muscle cells so these are the two cells of the brain that are basically erupting around the vessels and it involves Aggregates and in for cadazil it's not three proteins that Aggregates in parasites and Vascular muscle cells which makes uh vessels dysfunctional very quickly and those people develop white better disease at the age of 30 40 years old and they go towards cognitive detailing very rapidly it's very severe and Carousel about the same thing it's hdl1 htl HDR A1 sorry protein that is involved but Jay is there also the genetic form that has exactly the same features white metal disease micro bleeds raccoons and blood brain bioel issues”