Breakdown of tight junctions in the blood-brain barrier leads to neuroinflammation and disrupts nutrient transport and blood flow.

“happening as good when your bloodb brain barrier you know is dysfunctional right and then another point is the ability of things to interrupt and get into the brain that shouldn't so one of the things you know everybody learns in Pharmacology or medical school is that there are certain drugs that penetrate the bloodb brain barrier there are certain drugs that do not the implication being certain molecules can pass through certain molecules cannot well presumably the leakier that barrier is the more things that maybe we evolved to not have crossed that barrier do indeed cross and perhaps that's a part of what you just said right which is this increase in inflammation that is now coupled with an inability or a decreased ability to to clear out debris exactly”