In small vessel disease, the endothelium of microvessels becomes pro-inflamed and dysfunctional, and pericytes also show dysfunction.

“the founder the endothelium gets pro-inflamed so that's something that is very present in smallest so this is to give you an example I told you about the cell addition molecules that I expressed at the luminal side of the micro vessels of the brick when they get shedded they they are released into the the blood right and we know that people that do have smallest smallest of disease they are very high levels of soluble form of this cell addition molecules that can detect in biofluids so that's already a feature so the what we call on the table of dysfunctions the undertelium of the blood vessels are getting very inflamed and they don't do a proper job which imply also and there is some evidence that the pericites surrounding them are also dysfunctional very quickly in those disease”