A systems approach to cognitive decline and late-onset Alzheimer's disease requires a healthy vascular supply, adequate metabolic substrate availability, necessary nutrients, and the absence of impairing factors.

“trying to build this like systems approach to cognitive decline or late onset Alzheimer's disease and so then my current thought process is that all of these things are necessary healthy vascular Supply you know some kind of metabolic substrate that is taken up um and and available to neurons of the brain you know that you have the the nutrients required to build uh quality uh structure that you have um the absence of things that may impair some uh repair process”