In individuals with mild cognitive impairment, insulin infusion may transiently improve glucose uptake, suggesting a potential role for brain insulin resistance.

“if you take people with mild cognitive impairment we we there's been some experiments that actually suggest in these people insulin infusion can transiently improve glucose uptake but presumably that's because they're insufficiently getting glucose in the disease State yes this has been postulated yeah and this also suggested that there's brain insulin resistance yeah uh which is I I'd say an interesting concept uh and may play some role in this neurocognitive dysfunction”