Removing amyloid beta plaques has not consistently led to cognitive improvements and has sometimes caused negative outcomes.

“I know they did monoclonal antibodies or anti-sense oligonucleotides for amyloid beta protein and they got rid of the amyloid plaques and people did way worse that was some suggestion that when they eliminated amyloid beta plaques that they were actually serving some sort of a protective role and that we do see them accumulate in these neurodegenerative conditions and there may be amyloid and tau and there are different types of plaques and different types of neurofibrillary tangles but generally when we try and get rid of these plaques these neurodegenerative conditions don't get better”