Blood-brain barrier permeability changes can be measured using biomarkers and proteins in cerebrospinal fluid and plasma, and detected decades before cognitive impairment onset.

“but also in plasma and these have been shown by Dr slovic Dr Dr Montaine to occur I mean it's like decades before the onset of you know cognitive impairment and it's literally you can find it in more than 50% of all dementias so it's re and it's happening independent of of amalo accumulation T Tangles as well”