The primary glucose transporter at the blood-brain barrier, GLUT1, is reduced in Alzheimer's disease.

“but also the trans support I think you also alluded to this you're not getting things like glucose into the brain and in fact all these Transporters they're they're in the endothelial cells they're in these these these cells that are that are making up the blood-brain barrier and when you start to disrupt that blood-brain barrier those Transporters like are dysfunctional um you know so you're for example one of them is the glute one transporter this transports glucose into the brain as you start to get a disruption in blood-brain barrier function glucose Transporters they go down and and so you're talking about like not getting enough glucose into the brain which is again that's one of the you know pathological features of Alzheimer's disease right”

“you mentioned the glute one transporter as opposed to the glute 4 transporter and if my memory s correctly the brain has glute ones as opposed to glute fours and glute ones are insulin independent is that correct”

“it seems a bit counterintuitive that a condition that leads to insulin resistance of course type 2 diabetes is the essence of insulin resistance it seems counterintuitive that that would produce a hypom metabolic state in an organ whose glucose Transporters are insulin independent except when you explain it the way you did which is it's not the insulin resistance of the glute one transporter that's the problem the way it is for the glute 4 transporter in the muscle instead it's the actual mechanical disruption if I'm understanding correctly of that transporter because of the way it's no longer presumably held in place by the barrier itself that allows glucose to get across is that did I did I understand that correctly”

“and in fact all these Transporters they're they're in the endothelial cells they're in these these these cells that are that are making up the bloodb brain barrier and when you start to disrupt that bloodb brain barrier those Transporters like are dysfunctional um you know so you're for example one of them is the glute one transporter this transports glucose into the brain as you start to get a disruption in blood brain barrier function glucose Transporters they they go down and and so you're talking about like not getting enough glucose into the brain which is again that's one of the you know pathological features of Alzheimer's disease right not getting enough glucose into the brain”

“the main transporter of glucose at the blueberry barrier uh to make sure glucose comes to the brain is a good one so that's a pro that's a receptor group horn that has been found to be reduced in Alzheimer's disease so people have looked at again postpartembrane tissue bank and looking at the microvasculature and the bigger vessels and they found that as a respiration they have much less glute one at the prevailing barrier which means that there is less than a you know potential of the the flowing uh glucose in the blood that to penetrate the brain”