The evidence is convergent. Multiple independent sources reach the same conclusion, the underlying mechanism is well-characterized, and even the field's most cautious voices treat it as worth doing.
apo e4 it's a you know there's a variety of other mechanisms that happen but essentially you can measure the permeability of the blood-brain barrier looking at a variety of biomarkers and proteins in cerebral spinal fluid but also in plasma and these have been shown by Dr slovovic Dr montane to occur I mean it's like decades before the onset of you know cognitive impairment and it's literally you can find it in more than 50 of all dementias so it's re
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Bookmarking — the dossier-vs-overview split is the right call. Most of the time I want overview; sometimes I want receipts.
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it's re and it's happening independent of of amyloid accumulation Tau Tangles as well so uh it's you know either something that's happening before well before
in fact biomarkers of blood-brain barrier breakdown precede classical biomarkers of alzheimer's disease like tau tangles and amyloid beta-42 aggregates
not only neural Imaging is important but we also develop new biomarkers to look at uh in in plasma so in the blood or in cerebral spinal fluid we can measure markers and new markers of that gives us an idea of how leaky or the paramet vessels basically to make it simple simple