Lack of regular exercise causes the brain's capillaries to constrict and collapse, leading to neuron loss due to reduced oxygen and nutrient supply.

“we have to do some exercise some hierarchic exercise to make sure that the vessels we have tiny blood vessels in the brain so if you don't exercise you don't make sure that your heart is pumping and high rate regularly during the week those tiny vessels that are even smaller than your air in terms of diameter they will start to collapse and you you didn't have and remember the Capri is it's it represents 90 percent of your brain vasculature all these tiny blood vessels so if you start not see if you don't do enough exercise you you start chronically to have some vessels that will basically constrict and collapse and disappear meaning that the surrounding neurons that are here and they need oxygen and and nutrients and everything from these vessels if these vessels disappear you're going to lose neurons right”