Rhonda Patrick· PhD
Six 40-second intervals at 100% of VO2 max increased BDNF 4- to 5-fold more than light exercise for 90 minutes did.
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The headline is broadly defensible, but the qualifications matter. Effect sizes vary by population, the strongest claims rest on shorter trials, and credible voices push back on how it's typically framed.
Six 40-second intervals at 100% of VO2 max increased BDNF 4- to 5-fold more than light exercise for 90 minutes did.
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Previous studies have also found that high-intensity exercise is best for BDNF production.
Research shows that HIIT increases BDNF levels significantly more than moderate-intensity training, especially in the short term.