Increased blood pressure can damage capillaries by subjecting their endothelial walls to excessive mechanical pressures.

“these now leads to problems with the capillaries because these capillaries so the compensation for the macro vascular disease may actually be driving part of the damage at the micro vascular you're pushing now with a higher blood pressure through capillaries and these creates a pathology and this boundary we call the endothelial walls and these endothelial walls are now subjected to mechanical pressures that they were not designed to do”