Damage to the Papez circuit or thiamine deficiency can result in memory disorders like Korsakoff dementia.

“so if you affect this system anywhere in this system you get a memory disease and they just have different names so for example people have chronic alcohol they developed sometimes referred to as a where Korsakoff dementia mm-hmm also known as korsakoff's psychosis I can get this from B vitamin deficiencies as well b1 deficiency diamine deficiency particular you look at the pathology of the brain where is the damage the damage is primarily in the mammillary bodies”