Excitotoxicity, driven by excessive glutamate activity and often exacerbated by mitochondrial dysfunction, is a contributing factor in neurodegenerative diseases, stroke, traumatic brain injury, and ALS.

“Then the destroyer is... So, I mentioned epilepsy and excitotoxicity. There's a lot of evidence that in Alzheimer's, Parkinson's, definitely stroke, traumatic brain injury, ALS, all of those excitotoxicity is a factor that is neurons continuing to be excited by glutamate when they're in a compromised state, energetically, for example, with a stroke, or we think more subtly in Parkinson's or Alzheimer's, where there's mitochondrial dysfunction that's occurring.”