As Alzheimer's disease progresses, the brain produces less acetylcholine, and treatment involves inhibiting acetylcholinesterase.

“What's also interesting is that as Alzheimer's disease progresses, the brains of Alzheimer's patients make less and less acetylcholine. In fact, one of the first line of treatments for Alzheimer's disease is inhibition of an enzyme that degrades acetylcholine in the brain. This enzyme is known as acetylcholine eststerase.”